Peripheral proteins are made only of lipids, whereas integral proteins are made only of
carbohydrates.
Peripheral proteins occur only in prokaryotic cells, whereas integral proteins occur
only in eukaryotic cells.
Peripheral proteins are buried in the bilayer, whereas integral proteins lie only on its
surface.
Peripheral proteins lie on the membrane surface, whereas integral proteins are partially
or totally buried in the membrane.
Membrane proteins are classified according to their ease of extraction. Peripheral proteins lie on the
membrane surface, while integral proteins are partially or completely buried within the membrane.